• Model NO. :MIR-0889
• Customized: Customized
• Suitable for: Elderly, Adult
• Purity: No Less Than 99.5%
• Delivery Time: 1-3 Days Once Get Your Payment or Deposit
• Trademark: Miraclepharma
• Specification: SGS, GMP
• HS Code: 2934999090

• Powder: Yes
• Certification: GMP, ISO 9001, USP, BP
• State: Powder
• CAS#: 571190-30-2 /1374640-70-6 /870281-82-6
• Sample: Available
• Package: Fiber Drum or Aluminium Foil Bag or Carton
• Origin: Xi′an Shaanxi, China

GMP, SGS Certified With Purity Guarantee.

-1, Product Name: Idelalisib /CO-1686 /Palbociclib
-2, Specification & Standard: USP /EP /BP 99.5%

-3, CAS #: 571190-30-2 /1374640-70-6 /870281-82-6
-4, Description: White or light yellow crystalline powder

-5, Function :

PD-0332991 is selective and oral inhibitor of cyclin-dependent kinase 4/6 with IC50 values of 11nM and 16nM, respectively for CDK4 and CDK6 [1].

PD-0332991 is a highly specific inhibitor of CDK4/6. It is a potent anti-proliferative agent against Rb-positive tumor cells in vitro, subsequently inducing an exclusive G1 arrest. It has been reported to prevent tumor growth in disseminated human myeloma xenografts and induce G1 arrest in primary bone marrow cells [2].
PD-0332991 is also studied in breast cancer. It causes growth inhibition of ER-positive cell lines and 10/16 HER2-amplified cell lines. 100nM PD-0332991 can inhibit the phosphorylation of Rb in three more sensitive cell lines, resulting in prevention of cell cycle progression [2].

Palbociclib (codenamed PD-0332991, trade name Ibrance) is a drug for the treatment of ER-positive and HER2-negative breast cancer developed by . It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.

The drug IBRANCE was reviewed and approved under the Food and Drug Administration's (FDA) accelerated Priority Review and Breakthrough Therapy designation programs on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor-positive advanced breast cancer. A potentially confirmatory phase 3 trial, PALOMA-2, has fully enrolled patients. The PALOMA-3 trial announced in April 2015 that the addition of palbociclib was superior to fulvestrant alone for progression-free survival.

Palbociclib (PD-0332991) is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib is a highly specific inhibitor of cyclindependent kinase 4 (Cdk4) (IC50, 0.011 μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional protein kinases.

Applications/Usage

MDA-MB-453 breast carcinoma cells exposed to varying concentrations of PD 0332991 for 24 hours showed a significant increase in the percentage of cells in G1 in the presence of as little as 0.04 μmol/L PD 0332991 with a concomitant decline in other phases of the cell cycle. Maximum effects were attained at 0.08 μmol/L and an exclusive G1 arrest was maintained even at concentrations as high as 10 μmol/L, consistent with the complete absence of any other effects on the cell cycle.

Palbociclib is used with another medication (letrozole) to treat a certain type of breast cancer (estrogen-receptor-positive/HER2-negative breast cancer) in women after menopause. It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

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1, High quality under strict QC/QA system with GMP factory price

2, Fast and safe delivery with secure and discreet shipment

3, Providing complete services with our resource integration, we can thus create more competitive advantages for you!


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