Mammalian estrogenic hormone steroid 50-28-2 Improving Sexual Function Estradiol


Quick Detail:

Product Name	Estradiol
Alias	Turinabol
CAS NO	50-28-2
Appearance	White Crystalline Powder
MF	C18H24O2
MW	272.38
Assay	99% min
mp	178-179 °C(lit. )
storage temp.	2-8°C
Merck	14,3703
Active life	24 hours
Stability:	Stable. Incompatible with strong oxidizing agents.
Half-life	Oral Turinabol 16 hours
Synonyms	BETA-ESTRADIOL-16,16,17-D3; 17BETA-ESTRADIOL-16,16,17-D3; (+)-3,17-estradiol; (17b)-estra-1,3,5(10)-triene-3,17diol; (17)-estra-1,3,5(10)-triene-3,17diol; . Alpha. -Oestradiol; . beta. -Oestradiol; 17-. beta. -Estra-1,3,5(10)-triene-3,17-diol
Usage	Potent mammalian estrogenic hormone produced by the ovary.

Product Description:

Estradiol is a type of estrogen, the major sex hormone in women. It is secreted by the ovarian follicles. As the follicles grow and develop each month, they produce estradiol. This sets the rest of the reproductive cycle in motion.
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.
Estradiol transdermal skin patches are used to treat certain symptoms ofmenopause such as hot flashes, and vaginal dryness, burning, and irritation. This medication is also used to prevent postmenopausalosteoporosis, or to treat ovarian disorders. Estradiol transdermal may also be used for purposes not listed in this medication guide.

Application:
1. Female reproduction: In the female, estradiol acts as a growth hormone for tissue of the reproductive organs, supporting the lining of the vagina, the cervical glands, theendometrium, and the lining of the fallopian tubes. It enhances growth of the myometrium. Estradiol appears necessary to maintain oocytes in the ovary. During the menstrual cycle, estradiol produced by the growing follicle triggers, via a positive feedback system, the hypothalamic-pituitary events that lead to theluteinizing hormone surge, inducing ovulation. In the luteal phase, estradiol, in conjunction with progesterone, prepares the endometrium for implantation. During pregnancy, estradiol increases due to placental production. In baboons, blocking of estrogen production leads to pregnancy loss, suggesting estradiol has a role in the maintenance of pregnancy. Research is investigating the role of estrogens in the process of initiation of labor. Actions of estradiol are required before the exposure of progesterone in the luteal phase.
2. Sexual development: See also: Biochemistry of breast development
The development of secondary sex characteristics in women is driven by estrogens, to be specific, estradiol. These changes are initiated at the time of puberty, most are enhanced during the reproductive years, and become less pronounced with declining estradiol support after the menopause. Thus, estradiol producesbreast development, and is responsible for changes in the body shape, affecting bones, joints, and fat deposition. Fat structure and skin composition are modified by estradiol.
3. Male reproduction: The effect of estradiol (and estrogens in general) upon male reproduction is complex. Estradiol is produced by action of aromatase mainly in the Leydig cells of the mammalian testis, but also by some germ cells and the Sertoli cells of immature mammals. [6] It functions (in vitro) to prevent apoptosis of male spermcells. While some studies in the early 1990s claimed a connection between globally declining sperm counts and estrogen exposure in the environment, [8] later studies found no such connection, nor evidence of a general decline in sperm counts. [9][10] Suppression of estradiol production in a subpopulation of subfertile men may improve the semen analysis.
Males with certain sex chromosome genetic conditions, such as Klinefelter's syndrome, will have a higher level of estradiol.
4. Estradiol has a profound effect on bone. Individuals without it (or other estrogens) will become tall and eunuchoid, as epiphyseal closure is delayed or may not take place. Bone structure is affected also, resulting in early osteopenia and osteoporosis. Also, women past menopause experience an accelerated loss of bone mass due to a relative estrogen deficiency. Estradiol has complex effects on the liver. It can lead to cholestasis. It affects the production of multiple proteins, including lipoproteins, binding proteins, and proteins responsible for blood clotting.

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