CAS 2627-69-2 Pharmaceutival Raw Material Sarms Fat Burning Steroid Aicar


Quick Detail:

Product name	AICAR
Synonyms	ACADESINE; AICAR; AICA-RIBOSIDE; AMPK; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE; Z-RIBOSIDE
CAS	2627-69-2
Alias	Anadrol, Angrogen
EINECS	220-097-5
MF	C9H14N4O5
MW	258.23
Mol File	2627-69-2. Mol
mp	214-215 °C
storage temp	? 20°C
Appearance	Solid
Color	tan
Storage	Shading, confined preservation
Packing	1kg/aluminium foil bag or as required
Keywords	bodybuilding , steroid hormone , raw material powder
Usage	AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
Related Substances	Pharmaceutical Grade
Place of origin	Made in China
Delivery time	Within 24 hours upon receipt of payment
Shippment	EMS , DHL , TNT , FedEx , UPS

Product Description:

1. Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate). Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.

2. AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

3. Aicar refers to 5-aminoimidazole-4carboxamide riboncleotide which is an intermediate chemical in the generations of inosine monophosphate. Research for this product often focuses on protecting an animal's cardiac tissue from damage, after a myocardial infarct. This chemical is often applied in animal test subjects alongside GW1516 because it aicar can enhance the effects of this chemical during trials. GW1516 acts as a peroxisome proliferator-activated receptor delta that is limited to a research setting, due to its potential connections to cancer. Research indicates that this peptide could have an impact on improving treatment for cardiovascular disease, particularly when this condition is linked to diabetes, obesity or dyslipidemia.

Applications:

1. AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR& alpha and the coactivation of PPAR& alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

2. AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

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