Exenatide acetate
Synonyms: Exenatide acetate; Enfuvirtide acetate; Exenatide; His-gly-gly-gly-thr-phe-thr-ser-asp-leu-ser-lys-gln-met-glu-glu-glu-ala-val-arg-leu-phe-ile-glu-trp-leu-lys-asn-gly-gly-pro-ser-gly-ala-pro-pro-pro-ser-nh{2}; Exenatide acetate(exendin-4); Extendin-4; Unii-9p1872d4ol; His-gly-gly-gly-thr-phe-thr-ser-asp-leu-ser-lys-gln-met-glu-glu-glu-ala-val-arg-leu-phe-ile-glu-trp-leu-lys-asn-gly-gly-pro-ser-ser-gly-ala-pro-pro-pro-ser-NH2
CAS: 141732-76-5
MF: C186H284N50O62S
MW: 4244.60796
Product Categories: Peptide; Agonist; Nucleotides; Pharmaceuticals
Chemical Properties White Solid
Usage A 39-amino acid peptide originally isolated from the salivary glands of the Gila monster (Heloderma suspectum), differs from exendin-3 only in two positions close to the N-terminus. Application of exenatide causes an increase in acinar cAMP without stimulating amylase release. As an incretin mimetic, exenatide acts as agonist of the glucagon-like peptide-1 (GLP-1) receptor. As GLP-1, though with prolonged activity, exenatide augments the postprandial production of insulin and suppresses secretion of glucagon. For this reason, exenatide has found use as a medication of diabetes II.

Appearance: White powder
Single Impurity (HPLC): 1.0%max
Amino Acid Composition: ± 10% of theoretical
Peptide Content (N%): ≥ 80.0%
Water Content(Karl Fischer): ≤ 10.0%
Acetate Content(HPIC): ≤ 12.0%
MS(ESI): Consistent
Mass Balance: 95.0~105.0%

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