Chloramphenicol

Chloramphenicol
Synonyms: [theta-(theta, theta)]-; [R-(R*, R*)]-2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]ethanamide; 2,2-dichloro-n-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)-acetamid; 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R*, R*)]-Acetamide; 2,2-dichloro-n-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-acetamid; Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-nitrophenethyl
CAS: 56-75-7
MF: C11H12Cl2N2O5
MW: 323.13
EINECS: 200-287-4
Product Categories: Active Pharmaceutical Ingredients; Antibiotics for Research and Experimental Use; Biochemistry; Antibiotic Explorer; Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Chiral Reagents
Chemical Properties: White to grey-white crystalline powder
Usage: antibacterial, antirickettsial, inhibits protein synthesis. Chloramphenicol is unusual nitroaromatic metabolite produced by Streptomyces venezuelae, first published in 1947. Chloramphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Although restricted to ocular use, antibiotic resistance to other classes has refocused attention on this class. Chloramphenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Chloramphenicol has been extensively studied with over 35,000 literature citations.
Packing: 25kg/drum or as required

Chloramphenicol COA:

Test Items Specification Test Results
Characters A white to grayish-white or yellowish-white, fine crystalline powder or fine crystals, needles or elongated Qualified
Identification Meets the requirements Qualified
Melting range 149.0～153.0oC 149.0～151.5oC
PH 4.50～7.50(USP26) Meets the requirements(BP2002, EP2002) 5.51
Specific optical +17.00o～+20.00o(USP26) +18.50o～+20.50o(BP2002, EP2002) +19.72o
Related substances Meets the requirements Qualified
Chloride ≤100ppm(BP2002, EP2002) Qualified
Loss on drying ≤0.50%(BP2002, EP2002) 0.10%
Sulphated ash ≤0.10%(BP2002, EP2002) 0.04%
Crystallinity Meets the requirements(USP26) Qualified
Assay 97.00%～103.00%(USP26) 98.00%～102.00%(BP2002, EP2002) 99.74%
Conclusion Comply to the standard of BP2002, EP2002, USP26.