Trilostane CAS 13647-35-3

Name: Trilostane

Synonyms: (2-alpha, 4-alpha, 5-alpha, 17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car; 17-beta)-ph; 4-alpha, 5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril; 4-alpha, 5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile; 4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril

CAS: 13647-35-3

MF: C20H27NO3

MW: 329.43

EINECS: 237-133-0

Product Categories: Pharmaceuticals; Steroids

Chemical Properties: Tan Crystals

Usage: An inhibitor of steroid biosynthesis. Used as an adrenocortical suppressant. Used in the treatment of breast cancer. Antifungal, inhibits mitosis in metaphase. Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not 3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production oin LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.

Packing: 1kg/foil bag or as required

Trilostane COA:

Test Items Specification Test Results

Appearance white oralmost white, crystalline powder Conform

Solubility Freely soluble in water, practically insoluble or very slightly soluble in alcohol and in methylene chloride. Conform

Identification A The UV absorption spectrum of the sample shows an absorption maximum at 276nm. The specific absorbance at the Maximum is55 to 64. Conform

B Infraed absorption spectrophotometry. Conform

C Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution. Conform

D An orange-red color develop in methylene chloride layer. Conform

E It geves reaction (a) of sulphates. Conform

Appearance of solution Solution S is clear and not more intensely coloured than reference solution in BY6. Conform

Optical rotation negative 0.10° to +0.10°determined on solution S. +0.01°

Acidity or alkalinity NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red. Conform

Related substances Impurity J ≤0.20% Conform

Any other impurity ≤0.30% Conform

Total impurity ≤1.0% Conform

Boron ≤50ppm Conform

Sulphated ash ≤0.10% 0.06%

Loss on drying ≤0.5% 0.30%

Assay(on dried basis) 98.0~101.0% 99.5%

Conclusion The test results above BP2009

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