Bupivacaine Hydrochloride (CAS 14252-80-3 ) Local Anesthetic Drugs

Basic info:
Product Name : bupivacaine hydrochloride
Synonyms : 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide ; 1-Butyl-N-(2,6-
dimethylphenyl)-2-piperidinecarboxamide hydrochloride ; Bupivocoine HCl;
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride (1:1);
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride;
Bupivacaine Hcl; 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-,
monohydrochloride; 2', 6'-Pipecoloxylidide, 1-butyl-, hydrochloride (6CI); Marcaina;
BUPIVACAINE HYDROCHLORIDE ANHYDROUS
Molecular Formula : C18H31ClN2O2
Molecular Weight : 342.9039
InChI : InChI=1S/C18H28N2O. ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2) 9-8- 10-15(17)3; /h8-10,16H, 4-7,11-13H2,1-3H3, (H, 19,21); 1H
CAS Registry Number : 14252-80-3;18010-40-7
EINECS : 241-917-8
Boiling point : 423.4°C at 760 mmHg
Flash point : 209.9°C
Vapour Pressure : 2.24E-07mmHg at 25°C
Usage : Sodium channel blocker , local anesthetic


Clinical pharmacology:

Local anesthetics block the generation and the conduction of nerve impulses , presumably by increasing the threshold for electrical excitation in the nerve , by slowing the propagation of the nerve impulse , and by reducing the rate of rise of the action potential . In general, the progression of anesthesia is related to the diameter , myelination , and conduction velocity of affected nerve fibers . Clinically, the order of loss of nerve function is as follows : (1) pain , (2) temperature , (3) touch , (4) proprioception , and (5) skeletal muscle tone.

Usage:

Bupivacaine Hydrochloride is indicated for the production of local or regional anesthesia or analgesia for surgery , dental and oral surgery procedures , diagnostic and therapeutic procedures , and for obstetrical procedures.

Local anesthetics

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