Dexamethasone (CAS 50-02-2) Active Pharmaceutical Ingredients


Product Detials:

1. Product name Dexamethasone
2. Other name 16-alpha-methyl-9-alpha-fluoro-1,4-pregnadiene-11-beta, 17-alpha, 21-triol-3,2
3. CAS register number 50-02-2
4. EINECS 200-003-9
5. Molecular formula C22H29FO5
6. Appearance White crystalline powder
7. Molecular weight 392.46
8. Manufacturer NJBN STEROID
9. Melting point 262-264°C
10. Assay 98%
11. Usage A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth , and differentiation . Inhibits the induction of nitric oxide synthase

Product Description:

Active Pharmaceutical Ingredients Dexamethasone is used to treat many inflammatory and autoimmune conditions , such as rheumatoid arthritis and bronchospasm . Idiopathic thrombocytopenic purpura , a decrease in numbers of platelets due to an immune problem , responds to 40 mg daily for four days ; it may be administered in 14-day cycles . It is unclear whether dexamethasone in this condition is significantly better than other glucocorticoids.
It is also given in small amounts before and/or after some forms of dental surgery , such as the extraction of the wisdom teeth , an operation which often leaves the patient with puffy, swollen cheeks.

COA:

Product name	Dexamethasone
Appearance	White crystalline powder
Specific optical rotation	Between+72°and +80°	+76.4°
Chromatographic purity	Any individual impurity not more than 1.0% Total impurities not more than 2.0%	0.46% 1.13%
Loss on drying	Not more than 0.5%	0.11%
Residue on ignition	Not more than 0.2%	0.06%
Residual solvents	Methanol≤3000ppm Methylene Chloride≤600ppm Chloroform≤60ppm Tetrahydrofuran≤720ppm	364ppm Not detect out Not detect out Not detect out
Assay	Between 97.0% and 102.0%	98.1%
Micronixation	90% not more than 10 microns	90% not more than 10 aicrons