++++++++++ Paclitaxel(s) CAS 33069-62-4 Antiinflammatory 99% Purity API ++++++++++


++++++++++ Basic information ++++++++++

Product name	Paclitaxel
CAS	33069-62-4
MF	C47H51NO14
MW	853.91
EINECS	205-285-7
Appearance	White Powder
Purity	99%
Stability	Stable. Incompatible with strong oxidizing agents. Combustible.
Synonyms	N-BENZYL-BETA-PHENYLISOSERINE ESTER; PACLITAXEL, TAXUS BREVIFOLIA; PACLITAXEL, TAXUS SPECIES; PACLITAXOL; PACLITAXEL; TAXOL(TM); taxol a; TAXOL EQUIVALENT
Categories	Active Pharmaceutical Ingredients ; Pharmaceutical material and intermeidates; Antineopla stics ;Antineoplastic; APIs; Antitumors for Research and Experimental Use ; Biochemistry ; Natural Plant Extract; Intermediates & Fine Chemicals; Pharmaceuticals ; Natural Anti-cancer Medical Materials
Usage	An antineoplastic. Used in the study of structure and function of microtubles into tubulin. P aclitaxels is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxels is a mitotic inhibitor used in cancer chemotherapy.

++++++++++ Description ++++++++++


Paclitaxel is a monomer diterpenoid compound extracted from bark of the natural plant, taxus. It is a kind of
complex secondary metabolites and is currently known as the only kind drug that can promote microtubule polymerization and stabilize polymerized microtubules.

Isotopic tracing has showed that paclitaxels only binds to polymerized microtubules without reacting with
thenonpolymerized tubulin dimer. Cells will accumulate large amount of microtubules inside cells after exposure to paclitaxels with the accumulation of these microtubules being able to interfere with various kinds of
cellular functions, in particular, being able to stop cell division in the mitosis phase, blocking the normal cell division.

Paclitaxel is mainly applied to the treatment of ovarian and breast cancer and also has certain efficacy
in the treatment of lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumors.


++++++++++ COA ++++++++++

Test items	Quality index	Test items
Appearance	White crystalline powder	Appearance
Solubility	Soluble in water and glacial acetic acid, almost not soluble in ethanol and acetone (96%)	Solubility
Identification	Infrared absorption map complies with the tranexamic acid comparison map	Identification
PH	7.0~8.0	PH
Loss on drying	≤0.5%	Loss on drying
Residue on ignition	≤0.1%	Residue on ignition
Heavy metals	≤10ppm	Heavy metals
Sulphate ash	≤0.1%	Sulphate ash
Chloride	≤140ppm	≤140ppm
Assay	99.0%~101.0%	99.95%
	A≤0.1%, B≤0.2% C≤0.1%, D≤0.1%	A=0.043%, B=0.0608% C=0.0095%, D=0.0051%
Related substances	Total impurities (except A,B) ≤0.2%	Total impurities (except A,B)=0.015%
Conclusion	Complies

++++++++++ Application ++++++++++


Paclitaxels is always the first choice anticancer drugs in hosp itals around the world. In the past few
years, the cancer incidence around the world has nearly doubled compared to that at 10 years ago with lung,
breast and ovarian cancer and other malignancies also showing high incidence trend. These cancer
patients are the major users of paclitaxels. From the overall perspective, before the emergence of a new
plant anticancer drug being able to take its place, the sales of paclitaxels will only rise rather than fall.

It has good efficacy in the treatment of ovarian cancer and refractory ovarian cancer already being resistant
to existing platinum and breast cancer. It also has good prospect on the treatment of prostate cancer, head and
neck cancer, esophageal cancer, germ cell tumors, endometrial carcinoma, lymphoma, bladder cancer, upper
gastrointestinal cancer, small cell and non-small cell lung cancer.

According to the latest number released by the World Health Organization, the United States has become the
country of the world's first national high incidence of cancer with the annual newly cancer cases increasing by
1.4 million, accounting for 14% of the cases of cancer patients worldwide in that year. The United States has
remained the largest consumer of paclitaxels . With the increasing of US cancer incidence, the Paclitaxels is
used as the major anti advanced malignancy drug. It is believed that its sales will continue to maintain a rapid
upward trend. The United States and other developed countries, during the process of 10 years of clinical use,
have already summarized a set of optimal compatibility program for paclitaxel(s) and other anti-cancer drugs.
Paclitaxel(s) has become the "backbone" for the related health sector and therefore, the demand for
paclitaxel(s) drug will still in the potential of keeping rise.


++++++++++ Delivery Process ++++++++++

Sufficient stock

Sophisticated and professional logistic agent

Well-trained and disciplined packing team

Packing pictures and tacking code are provided within 24h after receiving the payment

After-sale service

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