| Purity: | 99% |
|---|---|
| Model Number: | 78613-38-4 |
| Brand Name: | NJBN STEROID |
| Grade Standard: | Medicine Grade |
| Type: | Antihypertensive |
| Place of Origin: | China (Mainland) |
| EINECS No.: | 78613-38-4 |
| MF: | C21H36ClNO |
| Other Names: | AMOROLFINEHCL |
| CAS No.: | 78613-38-4 |
| Sample: | Free |
| Market: | Worldwide |
Quick Details
Specifications
Amorolfine Hydrochloride For Antihypertensive CAS 78613-38-4 99%
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Amorolfine hydrochloride
Synonyms :
AMOROLFINEHCL; AmorolfineHCI; Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R, 6S)-rel-; Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-; Ro14-4767/002; (+/-)-cis-2,6-Dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholinehydrochloride; Amorolfinehydrochloride; (2R, 6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, hydrochloride (1:1)
CAS : 78613-38-4
MF : C21H36ClNO
MW : 353.97
Purity : 99%
Appearance: white powder
Related Categories: Antifungal (Topical); Antifungals for Research and Experimental Use; Biochemistry; anti-inflammatory drug; HYTRIN; antibiotics; intermediates; pharmaceutical raw materials; small molecule inhibitors
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Description of Amorolfine Hydrochloride
1. Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.
2. It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.
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Amorolfine Hydrochloride COA
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Usage of Amorolfine Hydrochloride
1. Research reagents, the product is a novel antifungal agent, the major inhibitory times ergot converted to the desired steroid ergosterol reductase and isomerase, resulting in sub-ergot alcohol accumulated substantial reduction ergot steroids, cause membrane structure and function is impaired, thereby killing the fungus.
2. Meanwhile amorolfine also cause abnormal chitin deposition lead to fungal growth disorders,
3. Also inhibit NADH oxidase and succinate cytochrome C reductase activity, a high pharmacological activity in vitro.
________________________________________________________________________________________________________________
Amorolfine hydrochloride
Synonyms :
AMOROLFINEHCL; AmorolfineHCI; Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R, 6S)-rel-; Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis-; Ro14-4767/002; (+/-)-cis-2,6-Dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholinehydrochloride; Amorolfinehydrochloride; (2R, 6S)-rel-4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-morpholine, hydrochloride (1:1)
CAS : 78613-38-4
MF : C21H36ClNO
MW : 353.97
Purity : 99%
Appearance: white powder
Related Categories: Antifungal (Topical); Antifungals for Research and Experimental Use; Biochemistry; anti-inflammatory drug; HYTRIN; antibiotics; intermediates; pharmaceutical raw materials; small molecule inhibitors
________________________________________________________________________________________________________________
Description of Amorolfine Hydrochloride
1. Amorolfine (or amorolfin), is a morpholine antifungal drug that inhibits Δ14-sterol reductase and cholestenol Δ-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes. Marketed as Curanail, Loceryl, Locetar, and Odenil, amorolfine is commonly available in the form of a nail lacquer, containing 5% amorolfine hydrochloride as the active ingredient. It is used to treat onychomycosis (fungal infection of the toe- and fingernails). Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.
2. It is a topical solution for the treatment of toenail infections. Systemic treatments may be considered more effective.
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Amorolfine Hydrochloride COA
|
TEST ITEM |
LIMT |
RESULTS |
|
Appearance |
White or almost white , hygroscople, crystalline powder |
conform |
|
Solubility |
slightly soluble in water, freely soluble in methhanol , soluble in aceton |
conform |
|
Identification |
to comply |
conform |
|
Appearance of solution |
The solution is clear and colorless |
conform |
|
Related substanceds (%) |
Impurity A≤0.4 |
0.3
nil |
|
heavy metals (%) |
≤0.001 |
< 0.001 |
|
loss on drying (%) |
≤0.5 |
0.18 |
|
sulphated ash (%) |
≤0.1 |
< 0.1 |
|
Assay (on dry basis) (%) |
99.0-101.0 |
99.68 |
|
granule size |
180 micron max |
conform |
|
conlusion |
conform to EP5.6 |
|
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Usage of Amorolfine Hydrochloride
1. Research reagents, the product is a novel antifungal agent, the major inhibitory times ergot converted to the desired steroid ergosterol reductase and isomerase, resulting in sub-ergot alcohol accumulated substantial reduction ergot steroids, cause membrane structure and function is impaired, thereby killing the fungus.
2. Meanwhile amorolfine also cause abnormal chitin deposition lead to fungal growth disorders,
3. Also inhibit NADH oxidase and succinate cytochrome C reductase activity, a high pharmacological activity in vitro.