Axitinib Raw Materials For Cancer Therapy 319460-85-0 99%

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Axitinib
Synonyms: AXITINIB; Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-; N-METHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE; N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide; AVERMECTINB; Axitinib for research; AG013736; N-Methyl-2-[[3-[(1E)- 2-(2-pyridinyl)ethenyl] -1H-indazol-6-yl]thio]benzamide
CAS: 319460-85-0
MF: C22H18N4OS
MW: 386.47
Purity: 99%
Appearance: White to off-White Powder
Categories:
All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Protein Kinase Inhibitors and Activators; Pfizer compounds; API; AG 013736


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COA

Items of analysis	Specification	Results
Description	off-white powder	Conforms
Loss on drying	NMT 1.0%	0.7%
Water content	NMT 0.5%	0.13%
Single impurity	NMT0.1%	0.07%
Total impurity	NMT 0.5%	0.29%
Purity(HPLC)	NLT 99.0%	99.71%
Conclusion	Qualified

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Description of Axitinib

Axitinib is a small molecule tyrosine kinase inhibitor developed . It has been shown to significantly inhibit growth of breast cancer in animal (xenograft) models and has shown partial responses in clinical trials with renal cell carcinoma (RCC) and several other tumour types. It has been shown to significantly Inhibit growth of breast cancer in xenograft models and has been successful in trials with renal cell carcinoma (RCC) and several other tumor types.

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