| Purity: | 99% |
|---|---|
| Model Number: | 57-63-6 |
| Brand Name: | NJBN STEROID |
| Grade Standard: | Medicine Grade |
| Type: | Ethynyl estradiol |
| Place of Origin: | China (Mainland) |
| EINECS No.: | 200-342-2 |
| MF: | C20H24O2 |
| Other Names: | Ethynyl estradiol |
| CAS No.: | 57-63-6 |
| Sample: | Free |
| Market: | Worldwide |
Quick Details
Specifications
Ethynyl estradiol 57-63-6 Plus Progestogen As Oral Contraceptive
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Product name Ethynyl estradiol
CAS NO 57-63-6
Purity 85%
MF C20H24O2
MW 296.4
EINECS 200-342-2
Appearance White Powder
Usage Anti Estrogen Steroids
Synonyms NOVESTROL; NEO-ESTRONE; ETHYNYLESTRADIOL; ETHINYLE
STRADIOL; LYNORAL; 17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL; 17ALPHA-ETHYNYLESTRADIOL; 17ALPHA-ETHINYLESTRADIOL
Categories Alcohols-and-Derivatives; Steroids; Acetylenes; Biochemistry;
Functionalized Acetylenes; Hydroxysteroids; Intermediates & Fine-Chemicals; Metabolites& Impurities; Pharmaceuticals; progestogen estrogen; ESTINYL; Hormone Drugs; Inhibitors
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Ethynyl estradiol description:
? Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen . It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives .
? Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later . It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme . Ethinyl Estradiol and its metabolites are excreted with the bile . Due to the effect of enterohepatic circulation a second peak is seen several hours later . Individually , wide variations exist in the overall absorption process , and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes . In circulation Ethinyl Estradiol is almost fully bound to plasma albumin . It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine , in part as glucuronide and sulfate conjugate .
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COA
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Hot Anti Estrogen Steroids :
Tamoxifen Citrate CAS: 54965-24-1
Clomiphene citrate CAS: 50-41-9
Toremifene citrate CAS: 89778-27-8
Exemestane CAS: 107868-30-4
Anastrozole CAS: 120511-73-1
Letrazole CAS: 112809-51-5
Methoxydienone CAS: 2322-77-2
Estradiol CAS: 50-28-2
Norgestrel CAS: 6533-00-2
____________________________________________________________________________________________________
Product name Ethynyl estradiol
CAS NO 57-63-6
Purity 85%
MF C20H24O2
MW 296.4
EINECS 200-342-2
Appearance White Powder
Usage Anti Estrogen Steroids
Synonyms NOVESTROL; NEO-ESTRONE; ETHYNYLESTRADIOL; ETHINYLE
STRADIOL; LYNORAL; 17ALPHA-ETHYNYL-DELTA1,3,5(10)-ESTRA-TRIENE-3,17BETA-DIOL; 17ALPHA-ETHYNYLESTRADIOL; 17ALPHA-ETHINYLESTRADIOL
Categories Alcohols-and-Derivatives; Steroids; Acetylenes; Biochemistry;
Functionalized Acetylenes; Hydroxysteroids; Intermediates & Fine-Chemicals; Metabolites& Impurities; Pharmaceuticals; progestogen estrogen; ESTINYL; Hormone Drugs; Inhibitors
____________________________________________________________________________________________________
Ethynyl estradiol description:
? Ethinyl Estradiol is hormonally effective by activating the estrogen receptor and thus is an estrogen . It finds its most common use in the estrogen-progestin combination preparations of oral contraceptives .
? Ethinyl Estradiol is absorbed in the small intestine and reaches a serum peak about 2 hours later . It undergoes extensive metabolism in the liver involving the cytochrome P450 3A4 isoenzyme . Ethinyl Estradiol and its metabolites are excreted with the bile . Due to the effect of enterohepatic circulation a second peak is seen several hours later . Individually , wide variations exist in the overall absorption process , and can be further modified by drugs that affect the enterohepatic circulation or liver enzymes . In circulation Ethinyl Estradiol is almost fully bound to plasma albumin . It is metabolized by hydroxylation of the aromatic ring and excreted in both feces and urine , in part as glucuronide and sulfate conjugate .
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COA
|
Items of analysis |
Specification |
Results |
|
Appearance |
White to creamy white, odorless, crystalline powder |
white crystalline powder |
|
Solubility |
Insoluble in water; soluble in alcohol, in chloroform, in ether, in vegetable oils, and in solutions of fixed alkali hydroxides. |
Conforms |
|
Identification |
A: IR B: UV |
Conforms |
|
Specific optical rotation |
-28°\u65374X -29.5° |
-29° |
|
Melting range |
180～186℃ |
183～184℃ |
|
Loss on drying |
≤1.0% |
0.29% |
|
Residual Solvents |
Acetone≤5000ppm; Ethanol≤5000ppm; Tetrahydrofuran≤720ppm |
235ppm; No Detectable; No Detectable |
|
Assay |
97.0～102.0% (on the dried basis) |
99.5% |
|
Particle Size |
90% ≤10μ |
Conforms |
|
Conclusion |
Qualified |
|
____________________________________________________________________________________________________
Hot Anti Estrogen Steroids :
Tamoxifen Citrate CAS: 54965-24-1
Clomiphene citrate CAS: 50-41-9
Toremifene citrate CAS: 89778-27-8
Exemestane CAS: 107868-30-4
Anastrozole CAS: 120511-73-1
Letrazole CAS: 112809-51-5
Methoxydienone CAS: 2322-77-2
Estradiol CAS: 50-28-2
Norgestrel CAS: 6533-00-2