Anti-Cyclic Citrullinated Peptide (Anti-CCP) ELISA Test 

 

Brief Introduction

This Test kit is used for in-vitro quantitative determination of the concentration of Anti-cyclic citrullinated peptide (Anti-CCP) in human serum or plasma sample, mainly used for clinical diagnosis of rheumatoid arthritis (RA).

Anti-CCP: An early, specific marker for rheumatoid arthritis (RA)

 

Anti-CCP antibodies are highly sensitive and specific for Rheumatoid Arthritis (RA). Studies show Anti-CCP test demonstrates an outstanding sensitivity of over 80% and a specificity of over 96%. The presence of anti-CCP antibodies can also be used to predict which patients will get more severe rheumatoid arthritis. The anti-CCP test enables clinicians to effectively distinguish RA patients from other RA-resembling diseases, even in cases where the rheumatoid factor (RF) is not discriminative. Anti-CCP antibodies can be detected very early in the course of RA.

The presence of anti-CCP is associated with significantly higher levels of erosions compared to rheumatoid factor and other parameters. Anti-CCP is an independent predictor of radiological damage and progression.

In 2009, Anti-CCP antibodies were recommended as diagnostic biomarker for early detection of rheumatoid arthritis in an ACR(American College of Rheumatology) meeting..

Benefits of Anti-CCP test in summary:

Use as an early and specific biomarker for rheumatoid arthritis

Demonstrate greater specificity than RF while maintaining or increasing sensitivity

Differentiate erosive from less or non-erosive RA

Help physicians decide when aggressive therapy with biologicals is needed

Monitor the treatment efficacy of drugs for RA