Toremifene citrate 89778-27-8 An antiestrogen and antineoplastic

Toremifene citrate

Product Name	Toremifene citrate
Synonyms	(z)-4-chloro-1,2-diphenyl-1-(4-(2-(n,n-dimethylamino)ethoxy)phenyl)-1-butene;2-(4- (4-chloro-1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin;2-h Ydroxy-1,2,3-propanetricarboxylate(1:1);fareston;fc1157a;nk622;TOREMIFENE CITRAT E;(z)-2-[4-(4-chloro-1,2-diphenyl-1-butenyl)phenoxy]-n,n-dimethyl-ethanamine 2-hydro Xy-1,2,3-propanetricarboxylate
CAS	89778-27-8
MF	C32H36ClNO8
MW	598.08
Chemical Properties	White-to-off-White Solid
Usage	Anesthetic
Usage	An antiestrogen and antineoplastic. Nonsteroidal antiestrogen structurally similar to Tamoxifen.

Description

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston, toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

COA

Items of analysis	Specification	Results
Description	White or like white crystalline powder	White crystalline powder
Solubility
Melting point	159~163oC	159.0~160.5oC
Identification	Must comply	Complies
E-isomer	≤0.5%	0.001%
Total relative substances	≤1.0%	0.1%
Heavy metals	≤10ppm	<10ppm
Loss on drying	≤1.0%	0.1%
	≤0.089%	0.0002%
Ethanol	≤0.5%	0
Acetone	≤0.5%	0.21%
	≤0.072%	0.0001%
Chlorobenzen	≤0.036%	0
Benzene	≤0.0002%	0
Residue on ignition	≤0.1%	0.04%
Assay	≥98.5%	99.7%
Conclusion	Qualified