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Purity: EP 7.0
Model Number: 55079-83-9
Brand Name: Tianrui
Grade Standard: Medicine Grade
Type: Vitamin ramification
Place of Origin: China (Mainland)
MF: C21H26O3
CAS No.: 55079-83-9
SPEC:EP7.0: Appearance: Yellow crystalline powder
Packing: 25kg/drum: Appearance: Yellow crystalline powder
Validity: 2 years: Place of origin: China

Specifications

Pharmaceutical Grade Steroids Bodybuilding Hormone Supplements Acitretin CAS 55079-83-9

 

Acitretin

Product Name: Acitretin
SPEC:EP7.0
CAS No.:55079-83-9

MFC21H26O3

Melting Point: 228-230°C

Packing: 25kg/drum

Appearance: Yellow crystalline powder

 

Storage: Sealed tightly and stored away from light in a cool and dry place.
Place of origin: China.

Validity: 2 years

Packing: 1kg/foil bag, or 25kg/carton drum

 

 

Product Description:

 

Acitretin (trade names Soriatane and Neotigason) is a second-generation retinoid. It is taken orally, and is typically used forpsoriasis.

It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life(t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. However, because acitretin can be reverse metabolised into etretinate which has an extremely long half-life, women must avoid becoming pregnant for at least 3 years after discontinuing acitretin. Therefore, acitretin is generally not recommended for women of child-bearing age with a risk of becoming pregnant.

Acitretin is an oral retinoid used in the treatment of severe resistant psoriasis. Because of the potential for problems and severe side effects it is generally used in only very severe cases of psoriasis that have been unresponsive to other treatments. It binds to nuclear receptors that regulates gene transcription. They induce keratinocytedifferentiation and reduce epidermal hyperplasia, leading to the slowing of cell reproduction. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer.

Patients that have received the medication are advised against giving blood for at least 3 years due to the risk of birth defects.

 

 

Applications:

 

Acitretin (CAS NO.55079-83-9) is a synthetic retinoid which is the major metabolite of etretinate. It is typically used for psoriasis. Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin.

 

 

 

Specification

 

Test Items

Standard

Result

Description

A yellow or greenish-yellow crystalline powder

conform

Identification

Shall comply

 All comply

Loss on dressing

0.5% 0.32%

Sulphated ash

0.1 0.09%

Heavy metals

20ppm

conform

Related substance

Individual impurities

0.3

0.21%

Total impurities

1.0%

0.40%

Assay(on dried basis)

98.0%-102.0%

99.5%

Conclusion

The results conform with EP6.0


Acitretin CAS 55079839

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