CAS 137862-53-4 Anti Hypertensive Medication Valsartan Medication

 

Quick Details:

Chemical Name: Valsartan
Molecular Formula: C24H29N5O3
Formula Weight: 435.5188
CAS NO.: 137862-53-4
Purity: 99%
Characteristics:white or white crystalline Powder
Quality standard: USP
Packaging: 25K g/drum
Usage:it's used for various types of Hypertension,and has the better protection effect on cardiovascular and renal. It can be routinely used by Hypertensive patients who are Myocardial Infarction, heart failure, proteinuria, diabetes. It's also can be combined with diuretics (such as hydrochlorothiazide)

 

Description:

Valsartan is an angiotensin-receptor Blocker that may be used to treat a variety of cardiac conditions including Hypertension, diabetic nephropathy and heart failure. Valsartan lowers blood Pressure by antagonizing the renin-angiotensin-aldosterone system; it competes with angiotensin II for binding to the type-1 angiotensin II receptor subtype and prevents the blood pressure increasing effects of angiotensin II.

 

 

 Specification:

 

Test Items		Standard	Result
Description		White or off-white powder,odorless,slightly hygroscopy   Hygroscopy	Qualified
Solubility		Free soluble in methanol and Ethanol,sparingly soluble in ethyl acetate,slightly soluble in Dichloromethane, particularly insoluble in water	Qualified
Identification		IR,HPLC Must conform to reference standard	Qualified
Absorbance at 420nm		≤0.02	＜0.01
Water(KF)		≤2.0%	0.4%
Residue on Ignition		≤0.1%	＜0.1%
Heavy Metals		≤10ppm	＜10ppm
Related compounds
D-valsartan	≤1.0%		0.49%
Butyryl-valsartan	≤0.2%		0.02%
Benzyl-valsartan	≤0.1%		N.D.
Any Other individual impurity	≤0.1%		0.03%
Total Impurities(ExcludingD-valsartan)	≤0.3%		0.11%
Residual Solvents
Ethanol		NMT5000ppm		N.D
Ethyl acetate		NMT5000ppm		2283ppm
Toluene		NMT890ppm		89ppm
Assay(HPLC)		98.0%-102.0%		100.3%
Conclusion		the results conform with USP37

 

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