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Pramocaine ( and, also known asPramoxine orPramoxine HCI) is a  discovered at Abbott Laboratories in 1953 and used as an. during research and development, pramocaine hydrochloride stood out among a series of alkoxy aryl alkamine ethers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. like other, pramocaine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

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Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.

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