Praziquantel is a fungicide for humans and animals,
Specifically for tapeworms and flukes. Broad fish tapeworm,
Chinese Schistosomiasis,particularly effective.

 Praziquantel is a list of drugs on the list of Essential
Medicines on the World Health Organization (WHO),
One of the world's most important drugs for basic public.

1.on the parasite can play two main pharmacological effects:
(1) parasitic muscle contraction and contraction caused by spastic paralysis. Schistosoma exposure to low concentrations of praziquantel only 20 seconds after the increase in body weight, drug concentration of 1mg / L or more, the body immediately strong contracture. Muscle muscle contraction may be associated with praziquantel increased parasite cell membrane permeability, so that intracellular calcium loss related.
(2) insect cortical damage and host immune function involved: praziquantel on the cortex of the body has a rapid and significant damage, causing syncytial skin swelling, vacuoles, the formation of bullae, prominent body surface, the final epidermal erosion Broken, almost all of the body disappeared, ring muscle and longitudinal muscle has quickly dissolved. In the host, 15 minutes after taking the drug can be seen in the body of vacuolar degeneration. Cortical damage, the impact of parasite absorption and excretion function, more importantly, its body surface antigen exposure, which susceptible to host immune attack, a large number of eosinophils attached to the skin lesions and invasion, to promote the parasite death. In addition, praziquantel can also cause secondary changes, so that the body membrane depolarization, cortical alkaline phosphatase activity was significantly reduced, resulting in inhibition of glucose intake, endogenous glycogen depletion. Praziquantel can also inhibit the synthesis of nucleic acid and protein.