Pharmacology and mechanism of action

Benzimidazole antiparasitic drug. like other Benzimidazoles, mebemdazole produces a degeneration of the parasite microtubule and irreversibly blocks glucose uptake in parasites. Inhibition of glucose Uptake cause depletion of energy stores in the parasite, eventually resulting In death. however, there is no effect on glucose metabolism in mammals.

Indications and clinical uses

Mebendazole is used in horses for treatment of Infections caused by large roundworms (Parascaris equorum), large strongyles (Strongylus edentatus, S.Equinus, and S.Vulgaris), small strongyles, and mature and immature (fourth larval stage pinworms [Oxyuris equi]). In dogs it has been Used for treatment of infections of roundworms (Toxocara canis), hookworms (Ancylostoma caninum and Uncinaria stenocephala), whipworms (Trichuris vulpis), and tapeworms (Taenia pisiformis).

Precautionary Information

Adverse reactions and side effects

Adverse reactions are rare. Mebendazole causes Occasional vomiting and diarrhea in dogs. Some report suggest idiosyncratic Hepatic reactions in dogs.

Contraindications and precautions

No contraindications have been reported.

Drug interactions

No drug interactions have been reported for animals.

Instructions for use

the powder for horses may be sprinkled directly on the Horse's grain or dissolved in 1 L of water and administered via stomach tube. for Dogs, it may be added directly to its food.

Patient Monitoring and laboratory tests

No specific monitoring is necessary.

Stability and storage

Store in a tightly sealed container, protected from Light, and at room temperature.

Stability of compounded formulations has not been Evaluated.

Regulatory Information.

Do not administer to horses intended for food.