| Appearance: | White Powder |
|---|---|
| Brand Name: | DEMEIKAI |
| Purity: | 95 |
| Type: | Pharmaceutical Intermediates |
| CAS No.: | 203849-91-6 |
| Application: | For Research Only |
| Place of Origin: | China (Mainland) |
| MF: | C41H66N6O6S |
| Other Names: | MMAD |
| Assay:: | 98% |
| Color:: | white powder |
Quick Details
Specifications
Product name:MonoMethyl Dolastatin 10
Synonyms:DeMethyldolastatin 10;MMAD;MonoMethyl Dolastatin 10;MonoMethylauristatin D;(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
CAS:203849-91-6
MF:C41H66N6O6S
General tips:for obtaining a higher solubility, please warm the tube at 37 and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 for several months.
MMAD Application:
MMAD is a highly potent inhibitor of tubulin. MMAD is one of the auristatins, which are used as the drugs of antibody drug conjugates (ADCs). In ADCs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of MAbs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. As a payload of ADCs, MMAD is used to target the tubulin of the tumor cells. It can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1]. Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). In the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics.
MMAD is a highly potent inhibitor of tubulin.
MMAD is one of the auristatins, which are used as the drugs of antibody drug conjugates (ADCs). In ADCs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of MAbs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. As a payload of ADCs, MMAD is used to target the tubulin of the tumor cells. It can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations.
Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). in the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics.
how to order?
1. Let me know the products with quantity you are interesting and your requirement, you will get the best offer.
2. after we confirm all the details about the order, Products will send out within 24 hours after we received your payment(MoneyGram,Western Union, T/T is accepted).
3. Tracking No. Will send to you within 2-3days.after 7days you will received your package.
4. We will take care of your order till parcel to your door, and expecting for your further feedback, 24 hours on line for after-sale service.
Synonyms:DeMethyldolastatin 10;MMAD;MonoMethyl Dolastatin 10;MonoMethylauristatin D;(S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
CAS:203849-91-6
MF:C41H66N6O6S
General tips:for obtaining a higher solubility, please warm the tube at 37 and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 for several months.
MMAD Application:
MMAD is a highly potent inhibitor of tubulin. MMAD is one of the auristatins, which are used as the drugs of antibody drug conjugates (ADCs). In ADCs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of MAbs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. As a payload of ADCs, MMAD is used to target the tubulin of the tumor cells. It can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations [1]. Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). In the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics.
MMAD is a highly potent inhibitor of tubulin.
MMAD is one of the auristatins, which are used as the drugs of antibody drug conjugates (ADCs). In ADCs, the therapeutic compounds and the high selectivity of antibodies are combined by the linkers. by taking advantage of antigen-selectivity of MAbs, it can deliver these cytotoxic drugs to antigen-expressing tumor cells, thus increasing both the efficacy and safety of therapy. As a payload of ADCs, MMAD is used to target the tubulin of the tumor cells. It can interfere with tubulin polymerization and induce rapid cell death at low picomolar concentrations.
Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). in the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics.
how to order?
1. Let me know the products with quantity you are interesting and your requirement, you will get the best offer.
2. after we confirm all the details about the order, Products will send out within 24 hours after we received your payment(MoneyGram,Western Union, T/T is accepted).
3. Tracking No. Will send to you within 2-3days.after 7days you will received your package.
4. We will take care of your order till parcel to your door, and expecting for your further feedback, 24 hours on line for after-sale service.
