Antihistaminic Histamine Receptor Antagonist White Pharmaceutical Powders Pheniramine Maleate CAS 132-20-7


Product Name: Pheniramine Maleate 
Synonyms: PROPHENPYRIDAMINE MALEATE;PHENIRAMINE MALEATE;PHENIRAMINE MALEATE SALT;PHENIRAMIN MALEATE;1-(n,n-dimethylamino)-3-(phenyl-3-alpha-pyridyl)propanemaleate;2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,bimaleate;2-(alpha-(2-(dimethylamino)ethyl)benzyl)pyridine,maleate;2-(alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1) 
CAS: 132-20-7 
MF: C20H24N2O4 
MW: 356.42 
EINECS: 205-051-4 
Product Categories: Antagonists;Histaminergics;Neurotransmitters;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Melting point  104-108C 
Water Solubility  >=1 g/100 mL at 24 C 
Stability: Stable. Incompatible with strong oxidizing agents. 
Chemical Properties white powder 
Usage Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria. 
Usage Antihistaminic;H1 antagonist 
Usage A H1 histamine receptor antagonist. 
Usage Used medicinally as an antihistaminic (merck). 


Pheniramine Description

Pheniramine (INN, trade name Avil, among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria. It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine. Pheniramine is also commonly found in eyedrops used for the treatment of allergic conjunctivitis.

Pheniramine is generally sold in combination with other medications, rather than as a stand-alone drug, although some formulations are available containing pheniramine by itself. as an example, Neo Citran contains pheniramine.


Side effects

Pheniramine may cause drowsiness or bradycardia, and over-dosage may lead to sleep disorders. Overdose may lead to seizures, especially in combination with alcohol. People combining with cortisol in the long term should avoid pheniramine as it may cause lowered levels of adrenaline (epinephrine) which may lead to loss of consciousness.