1536473-72-9
TBuBrettPhos-Pd-G3
Synonym: tert-BuBrettPhos-Pd-G3, 
[(2-Di-tert-butylphosphino-3,6-dimethoxy-2,4,6-triisopropyl-1,1-biphenyl)-2-(2-amino-1,1-biphenyl)]palladium(II) methanesulfonate

CAS Number: 1536473-72-9
Formula: C44H62NO5PPdS
Formula Weight: 854,43 g/mol
Appearance (Color) White to Very Dark Green to Very Dark
ISO9001 Manufacturer 
Standard laboratory 
Ligands catalysts synthesis pharmaceutical compounds electronic intermediates

Assay  96%
Mp  119-131 °C
Caution: air sensitive 
Shelf life:12 month 
Supplier: LPBchem-Benjamin

Related Categories
Buchwald 3rd Generation Palladacycles, Buchwald Ligands and Complexes, Catalysis and Inorganic Chemistry, Chemical Synthesis, Cross-Coupling,
Homogeneous Pd Catalysts, Palladium Catalysts

General description
TBuBrettPhos Pd G3 is a third generation (G3) Buchwald precatalyst that can be used in cross-coupling reactions for the formation of C-C, CN, CO, CF, CCF3, and CS bonds. It is air-, moisture-, and thermally-stable and is highly soluble in a wide range of common organic solvents. Some of its unique features include lower catalyst loadings, shorter reaction time, efficient formation of the active catalytic species and accurate control of ligand: palladium ratio.

Application
TBuBrettPhos Pd G3 has been used as a precatalyst for the N-arylation of amino acid esters with aryl triflates under mild reaction conditions and minimal racemization of the amino acid ester. It may also be used to catalyze the conversion of aryl halides to phenols in the presence of benzaldoxime as a hydroxide surrogate