Peony skin is one of the traditional Chinese medicines commonly used for cold blood and live blood, and is often used in clinical treatment of cardiovascular disease. with the development and research of the new use of traditional Chinese medicine, the extensive pharmacological effect of peony skin is more and more experimental basis, the new technology of extracting peony skin total gin by large-hole adsorption resin is recognized by people, its process is simple and feasible, easy to parse, and the resin can be regenerated with potential industrial value.