Vardenafil
CAS Number: 224785-91-5
Molecular formula: C23H33ClN6O4S
Molecular weight: 525.06
EINECS number:607-088-5


Vardenafil hydrochloride is a drug for the treatment of male erectile dysfunction, and is the first-line treatment drug for erectile dysfunction. It was successfully developed by Bayer, Germany, and was first listed in the United States in 2002. like sildenafil, it belongs to the second-generation type 5 phosphodiesterase inhibitor, with a very rapid onset, taking about 15-20 minutes. the effect is ten times stronger than sildenafil. Clinical data show that 50% to 60% of male diabetic patients over the age of 50 suffer from erectile dysfunction, and erectile dysfunction caused by nerve and blood vessel damage caused by diabetes is particularly difficult to treat. the potent and selective phosphodiesterase 5 (PDE5) inhibitor vardenafil developed by Bayer may bring good news to patients with erectile dysfunction caused by diabetes. these drugs are used as one-time treatment drugs. after oral administration about 1 hour before sex, they can selectively inhibit the effect of PDE5, block the degradation of cGMP induced by nitric oxide (NO) released after sexual stimulation, increase its concentration, and relax arteries and blood vessels. Smooth muscle, enhance erectile function, and occasionally have adverse reactions such as headache, blushing, stomach discomfort, and color vision disorders.
Three selective phosphodiesterase type 5 (PDE5) inhibitors: Sildenafil (Cialis), Vardenafil Hydrochloride (Levitra) and Tadalafil are all first-line drugs for the treatment of ED; In terms of effectiveness, safety and tolerability, PDE5 inhibitors are not significantly different from apomorphine; intracavernosal injection of prostaglandin E1 is the second-line treatment for ED; and intraurethral prostaglandin E1 is more effective than intracavernous the injection of prostaglandin E1 is worse. It is concluded that PDE5 inhibitors are effective, well-tolerated and safe in the treatment of ED; the treatment methods of apomorphine, intracavernous injection of prostaglandin E1 and intraurethral administration of prostaglandin E1 are also effective and have better results. Tolerance


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Guangzhou Tengyue Chemical Co., Ltd. Is based in Guangzhou, Guangdong Province. It mainly uses chemical synthesis of raw materials, preparations, pharmaceutical intermediates, chemical raw materials, chemical antiseptics, flavors and fragrances, food additives, etc. The product integrates research and development, production, management and sales into a large-scale comprehensive high-tech enterprise. 
Our company mainly produces anesthetic powders and steroid powders. 


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