| Brand Name: | An qing |
|---|---|
| Appearance: | White to off-white |
| Purity: | 98% |
| Grade Standard: | Industrial Grade |
| CAS No.: | 119753-54-0 |
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Brigatinib is a small molecule inhibitor of both ALK and EGFR [195]. In preclinical models, " triple-mutant EGFR" -positive cells (activating EGFR mutation/ T790M/C797S) responded to the combination of brigatinib with an anti-EGFR monoclonal antibody, cetuximab or panitumumab [196]. Single-agent activity of brigatinib in a phase I/II trial was only 5% [197], possibly compounded by low plasma concentrations [196], but the addition of an anti-EGFR monoclonal antibody remains to be clinically tested. the preclinical data with brigatinib and EAI045?In laboratory models with a C797S mutation demonstrate that combination therapies with an anti-EGFR monoclonal antibody may lead to overcoming resistance
to osimertinib.
to osimertinib.