| Brand Name: | An qing |
|---|---|
| Appearance: | White |
| Purity: | 98% |
| Grade Standard: | Industrial Grade |
| CAS No.: | 1365267-27-1 |
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TheabilityofX-376toinhibitthegrowthofdifferentcancercelllinesharboringALKfusionsorpointmutationsistested.X-376ispotentinH3122lungcancercellsharboringEML4-ALKE13;A20(IC50:77nM).X-376isalsopotentinH2228lungcancercellsharboringEML4-ALKE6a/b;A20(IC50:57nM).Furthermore,X-376ispoChemicalbooktentinSUDHL-1lymphomacellsharboringNPM-ALK(IC50:32nM).X-376alsoinhibitsSY5YneuroblastomacellsharboringALKF1174L,MKN-45gastriccarcinomacellsharboringMETdependent,HepG2cellsandPC-9lungcancercelllinesharboringEGFRexon19delwithIC50sof142nM,150nM,15.137μMand3.062μM,respectively.