at present,there are many anti-tumor drugs,but no ideal anti-laryngocarcinoma drug with high efficiency and low toxicity has been found.Therefore,the study of high-efficiency,low-toxicity,and even natural anti-tumor drugs to enrich the prevention and treatment of laryngeal cancer has become the focus and focus of many experts and scholars.Indole-3-carbinol(indole-3-carbinol)is a tumor chemopreventive substance,which can be extracted from cruciferous vegetables(such as broccoli,radish and cauliflower,etc.).Indole-3-carbinol can inhibit the occurrence and development of various tumors.

1.Inhibitory effect of indole-3-carbinol on the proliferation of laryngeal carcinoma Hep-2 cells

Indole-3-carbinol can inhibit the proliferation of Hep-2 cells,and its induction of apoptosis may be related to the inhibition of Livin protein expression.

with the increase of indole-3-carbinol concentration,the expression of Livin gradually decreased,suggesting that the expression of Livin protein was negatively correlated with the apoptosis rate of human laryngeal carcinoma cell line Hep-2 after the action of indole-3-carbinol.It may play a certain role in the apoptosis of human laryngeal carcinoma cells induced by indole-3-carbinol.Indole-3-carbinol can only induce apoptosis of cancer cells,and is safe and non-cytotoxic to non-tumor cells.Because of its high-efficiency,non-toxic and natural anti-tumor properties,indole-3-carbinol can be one of the candidates for cancer prevention and treatment.the molecular mechanism of indole-3-carbinol inhibiting laryngeal cancer cells still needs further study in order to provide a theoretical basis for future clinical drug research.

2.Application areas

Health products and pharmaceutical intermediates.