the following example is for you reference.


Main Advantages:Hydomycin B, an aminoglycoside antibiotic produced by the metabolism of Streptomyces hydatidis, inhibits protein synthesis by interfering with 70S ribosomal transpositions and inducing misreading of the mRNA template, thereby killing prokaryotes (e.g., bacteria), eukaryotes (e.g., yeast, fungi), and higher mammalian eukaryotes.

  

 

Technical details:the E. Coli derived hydomycin resistance gene (hyg or hph) encodes hydomycin B phosphotransferase, which converts hydomycin B into a non-biologically active phosphorylated product, thus playing a detoxification role. In response to this principle, hygromycin B is a very useful selective marker for screening and maintenance of cultured prokaryotic or eukaryotic cells successfully transfected with hygromycin resistance genes. In addition, due to differences in mode of action, it is often used in combination with G418, Zeocin?, and Blasticidin S for selection of double-resistant positive cell lines. Hydomycin B can also be used as an antiviral agent because it selectively penetrates into cells that enhance permeability due to viral infection and has the effect of inhibiting translation. It can also be mixed into animal feed to repel insects.

  

 

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