[Chief Ingredients] Radix Astragali seu Hedysari(Huangqi), Poria (Fuling), Radix Codonopsis Pilosulae(Dangshen), etc. [Functions and Indication] It has the functions of tonifying spleen and kidney, benefiting qi and body constitution. It can obviously improve the symptoms of spleen deficiency, increase the specific and non-specific immunity. Indicated for the syndrome of spleen and kidney deficiency, deficiency of vital energy manifested as fatigue, poor appetite, weak and sour sensation of the lower back and knees, edema, cough and asthma. It is indicated for chronic diseases accompanied with hypoimmunity and disorder of immune function. [Specification] 3g each pack, 21 packs each box. [Contraindication] Contraindicated for children and pregnant women. [Side Effects] There is not any side effect. [Storage] Tightly sealed and kept in a cool and dry place. Keep from moisture. [Term of validity] 2 years -------------------------------------------------------------------------------- [Pharmacological Actions] 1. Effect on weight and frigostability of mice with spleen vacuity: Mongor Granule have satisfactory effects to treat symptoms related to mouse spleen vacuity, e.g. sloppy stool, torpid intake, hypoactivity, feeble limbs, emaciation, etc. Taking Mongor Granule, mice have significant increase of weight and frigostability. 2. Effect on natatory time of mice with spleen vacuity: Mice administered Mongor Granule demonstrate a prolonged natatory time. 3. Effect on mice hypoxia tolerance: Compared to the reference group, mice administered Mongor Granule survive longer in hypoxia condition with normal air pressure (in board opening bottle with volume of 250ml, containing 15g soda lime). 4. Effect on mice immunity: Among mice administered Mongor Granule , Spleen and thymus weight increase obviously. Mongor Granule has shown on mice a counteraction to cytoxans inhibitory effects towards immune organs. It also enhances phagocytosis of macrophages in mice enterocelia, and improves humoral immunity. The testing scores of the above aspects show a great difference between the tested group and the reference group. In conclusion, Mongor Granule can improve conditions among mice with spleen vacuity, reduce mortality in frigostability test, prolong natatory time, enhance mice hypoxia tolerance, increase weight of spleen and thymus, counteract against inhibitory effects on immune organs induced by cytoxan, promote phagocytosis of enterocelia macrophages, and increase animal antibody production as well as serosaguineous bronze . The above results indicate that Mongor Granule improves mechanism states of mice with spleen vacuity, enhances stress competence and non-specific immunity, strengthens mechanism defense abilities and thus is good for diseases prevention. [Toxicity Test] 1. Acute toxicity test: Giving to mice, through oral route, 50% Mongor Granule suspended liquid 20ml/kg (i.e. 60g/kg, about 120 times of human adult dosage. during 7 days? observation, mice?s intake, output and behaviors are all normal. There is no adverse reaction or death occurred. 2. Long term toxicity test: With oral administration of Mongor Granule to mice in small, medium and large dosages, for continuous 90 days, mice?s behaviors and growth are normal, no abnormalities seen in mice?s intake, fur, stools. There is also a weight gain, which compared to the time before administration, is significant; while compared among the three dosages groups, does not show dist