There are several scientific studies supporting that high-molecular-weight polysaccharides can produce greater immune stimulating effects. The primary active compound, the hot water-extracted polysaccharides of Grifola Umbellata, is composed of B(1-3) (1-6) D-glucans. In recent Japanese animal studies on the anti-cancer effects of various medicinal mushrooms, Grifola Umbellata produced the second best result of all. The higher ordered structures (triple helices) of high- molecular-weight B-D-glucans are believed to be responsible for the considerable immunomodulatory activity (Maeda et al., 1988).