Purity: | >99% |
---|---|
Model Number: | CAS: 82009-34-5 |
Brand Name: | NJBN STEROID |
Grade Standard: | Medicine Grade |
Type: | Auxiliaries and Other Medicinal Chemicals |
Place of Origin: | China (Mainland) |
EINECS No.: | 279-875-8 |
MF: | C16H26N2O5S |
Other Names: | CILASTATIN;(z)-7-[(2s)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1s) |
CAS No.: | CAS: 82009-34-5 |
Payment Terms:: | T/T, Western Union, Money Gram |
Delivery Ways: | EMS, Hkems, TNT, DHL, FedEx, UPS etc. |
Shipment Time: | 3-5 Working Days After Receiving Payment |
Usage: | Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct. |
Quick Details
Specifications
Quick Detail:
Product Name:
Synonyms:CILASTATIN;(z)-7-[(2s)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(r-(r*,s*-(z)))-)carbonyl)amino);mk-791;Cilastain;(2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid;Cilastatin acid;(Z)-7-[(2S)-2-Amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1S)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid
CAS NO. :
MF : C16H26N2O5S
EINECS:279-875-8
MW : 358.45
Appearance : White to Light-Yellow Crystalline Powder
Purity : >99%
Grade : Pharmaceutical Grade & Veterinary Grade
Storage: Closed, shading preservation
Brand Name:NJBN STEROID
Delivery time : Within 24 hours upon receipt of payment
Shipment : EMS, DHL, TNT, FedEx, UPS
Usage :Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct.
Description:
Cilastatinis a chemical compound which inhibits the humanenzymedehydropeptidase.
Dehydropeptidase is an enzyme found in thekidneyand is responsible for degrading theantibioticimipenem. Cilastatin can therefore be combinedintravenouslywith imipenem in order to protect it from dehydropeptidase and prolong its antibacterial effect. Imipenem alone is an effective antibiotic and can be given without the cilastatin. Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependentbeta-lactamasethat usually confer antibiotic resistance to certain bacteria; more precisely thecarbapenemfamily of antibiotics. This property is due to the physico-chemical similarities betweenmembrane dipeptidase(MDP), the compound it is usually set to target, and the bacterial metallo-beta-lactamase carried by the CphA gene[1]Therefore, Cilastatin is considered abeta-lactamase inhibitor, not an antibiotic per se.
Application:
Prevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct
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